Dario Alessi is Director of the Protein Phosphorylation and Ubiquitylation Unit, a Medical Research Council unit in the School of Life Sciences at Dundee University, where he also heads the Dundee Signal Transduction Therapy Unit, a collaboration between academic researchers and pharmaceutical companies. His research focuses on disruptions in protein phosphorylation and ubiquitylation and their link to a series of human diseases, and has contributed to the understanding of disease relevant signal transduction pathways including PDK1 (diabetes and cancer), LKB1 (cancer) and WNKs (blood pressure). Much of his current work concerns the LRRK2 protein kinase and how mutations in this enzyme cause Parkinson’s disease. Professor Alessi is a Fellow of the Royal Society, which awarded him its Francis Crick Prize Lectureship, and of the Academy of Medical Sciences. His multiple distinctions include the Gold Medal of the European Molecular Biology Organization.